Absolute coronary flow and microvascular resistance reserve in patients with severe aortic stenosis.
Pasquale PaolissoEmanuele GallinoroMarc VanderheydenGiuseppe EspositoDario Tino BertoloneMarta BelmonteNiya MilevaKonstantinos BermpeisCristina De ColleDavide FabbricatoreAlessandro CandrevaDaniel MunhozIvan DegrieckFilip CasselmanMartin PenickaCarlos ColletJeroen SonckFabio MangiacapraBernard de BruyneEmanuele BarbatoPublished in: Heart (British Cardiac Society) (2022)
In patients with severe AS and non-obstructive coronary artery disease, with the progression of LV hypertrophy, the compensatory mechanism of increased resting flow maintains adequate perfusion at rest, but not during hyperaemia. As a consequence, both CFR and MRR are significantly impaired.
Keyphrases
- aortic stenosis
- coronary artery disease
- transcatheter aortic valve replacement
- ejection fraction
- aortic valve replacement
- transcatheter aortic valve implantation
- aortic valve
- left ventricular
- early onset
- percutaneous coronary intervention
- coronary artery bypass grafting
- cardiovascular events
- coronary artery
- heart rate
- heart rate variability
- drug induced
- contrast enhanced
- computed tomography
- blood pressure
- atrial fibrillation