Plasma Metabolomics for Discovery of Early Metabolic Markers of Prostate Cancer Based on Ultra-High-Performance Liquid Chromatography-High Resolution Mass Spectrometry.
Xiangping LinLucie LécuyerXinyu LiuMohamed N TribaMelanie Deschasaux-TanguyAïcha DemidemZhicheng LiuTony PalamaAdrien RossaryMarie-Paule VassonSerge HercbergPilar GalanPhilippe SavarinGuo-Wang XuMathilde TouvierPublished in: Cancers (2021)
Our results support the dysregulation of amino acids and sphingolipid metabolism during the development of PCa. After validation in an independent cohort, these signatures may promote the development of new prevention and screening strategies to identify males at future risk of PCa.
Keyphrases
- high resolution mass spectrometry
- ultra high performance liquid chromatography
- tandem mass spectrometry
- liquid chromatography
- prostate cancer
- mass spectrometry
- gas chromatography
- simultaneous determination
- amino acid
- small molecule
- radical prostatectomy
- solid phase extraction
- genome wide
- ms ms
- high resolution
- dna methylation