Emerging Mutual Regulatory Roles between m 6 A Modification and microRNAs.

N 6 -metyladenosine (m 6 A), one of the most common RNA methylation modifications in mammals, has attracted extensive attentions owing to its regulatory roles in a variety of physiological and pathological processes. As a reversible epigenetic modification on RNAs, m 6 A is dynamically mediated by the functional interplay among the regulatory proteins of methyltransferases, demethylases and methyl-binding proteins. In recent years, it has become increasingly clear that m 6 A modification is associated with the production and function of microRNAs (miRNAs). In this review, we summarize the specific kinds of m 6 A modification methyltransferases, demethylases and methyl-binding proteins. In particular, we focus on describing the roles of m 6 A modification and its regulatory proteins in the production and function of miRNAs in a variety of pathological and physiological processes. More importantly, we further discuss the mediating mechanisms of miRNAs in m 6 A modification and its regulatory proteins during the occurrence and development of various diseases.