New Perspectives for the Rescue of Cognitive Disability in Down Syndrome.

Renata Bartesaghi Tarik F Haydar Jean Maurice Delabar Mara DierssenCarmen Martínez-CuéDiana W Bianchi

Published in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2016)

Down syndrome (DS) is a relatively common genetic condition caused by the triplication of human chromosome 21. No therapies currently exist for the rescue of neurocognitive impairment in DS. This review presents exciting findings showing that it is possible to restore brain development and cognitive performance in mouse models of DS with therapies that can also apply to humans. This knowledge provides a potential breakthrough for the prevention of intellectual disability in DS.

Keyphrases

intellectual disability
autism spectrum disorder
endothelial cells
mouse model
healthcare
multiple sclerosis
copy number
bipolar disorder
white matter
genome wide
gene expression
induced pluripotent stem cells
dna methylation
risk assessment
climate change
cerebral ischemia