Population pharmacokinetic/pharmacodynamic models of JNJ-64794964, a toll-like receptor 7 agonist, in healthy adult participants.
Liviawati S WuYue HuEdward J GaneLeen SlaetsAn De CreusYanhua DingJunqi NiuChristian SchwabeNele GoeyvaertsZhongnan XuDandan HuoMarianne TuefferdInge VerbruggePieter Van RemoortereUllrich SchwertschlagJoris VandenbosschePublished in: Antiviral therapy (2023)
PK/PD models well characterized the time course of immune system markers in healthy adults. Our results supported sex and race as covariates on JNJ-4964 responsiveness, as well as circadian rhythms and negative feedback as homeostatic mechanisms that are relevant in TLR7-induced type I IFN responses.