Water-Soluble Porphyrin-Based Nanoparticles Derived from Electrostatic Interaction for Enhanced Photodynamic Therapy.
Yu-Xin LiYamin LiuHui WangZhan-Ting LiDan-Wei ZhangPublished in: ACS applied bio materials (2022)
Pyrrole and porphyrin-derived nanoparticles have great potential use in bioimaging and therapy because of their unique magnetic, optical, and other photophysical properties, whereas the poor solubility in aqueous solution is one of the drawbacks of current photosensitizers for their photodynamic therapy (PDT) applications. Here, we developed a kind of water-soluble porphyrin-based nanoparticles that are coassembled mainly by the electrostatic interaction of anionic porphyrins and cationic tetraphenylmethane derivative. No aggregation-caused quenching (ACQ) was detected for these nanoparticles. In addition, the simple porphyrin transformation into nanoparticles improved their ability to generate reactive oxygen species singlet oxygen ( 1 O 2 ), which is an important factor causing apoptosis. The coassembled water-soluble porphyrin-based nanoparticles exhibited enhanced antitumor efficiency via PDT both in vitro and in vivo .
Keyphrases
- photodynamic therapy
- water soluble
- fluorescence imaging
- walled carbon nanotubes
- stem cells
- mass spectrometry
- energy transfer
- molecular dynamics simulations
- cell death
- signaling pathway
- bone marrow
- climate change
- cell proliferation
- mesenchymal stem cells
- single molecule
- simultaneous determination
- liquid chromatography
- tandem mass spectrometry