Phenotypic characterization of circulating tumor cells in the peripheral blood of patients with small cell lung cancer.

Ippokratis MessaritakisEleni PolitakiAthanasios KotsakisEleftheria-Kleio DermitzakiFilippos KoinisEleni LagoudakiAnastasios KoutsopoulosGalatea KallergiJohn SouglakosVassilis Georgoulias

Published in: PloS one (2017)

CK+/Ki67+, CK+/M30+ and CK+/Vim+ CTCs represent distinct subpopulations of CTCs in patients with SCLC, can be detected even in the absence of detectable CTCs by CellSearch; CK+/Ki67+ and CK+/Vim+ CTCs are associated with unfavorable clinical outcome.

Keyphrases

circulating tumor cells
protein kinase
small cell lung cancer
peripheral blood
circulating tumor
neoadjuvant chemotherapy
squamous cell carcinoma
radiation therapy
cell free