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Concordance of PD-L1 expression in matched urothelial bladder cancer specimens.

Joep J de JongHans StoopDaan NieboerJoost L BoormansG J L H Geert van Leenders
Published in: Histopathology (2018)
Urothelial bladder cancer patients showed fair agreement of PD-L1 assay outcome in cystectomies and matched TURB or lymph node specimens. PD-L1 expression was discordant more often after neoadjuvant therapy. Therefore, immune-checkpoint inhibitor studies should take into account specimen type and neoadjuvant therapy in assessing the predictive value of PD-L1 expression.
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