Neoxanthin prevents H2O2-induced cytotoxicity in HepG2 cells by activating endogenous antioxidant signals and suppressing apoptosis signals.

Deepika Udayawara RudreshTehreem MaradagiNimish Mol StephenAyyadurai NiraikulamKamini Nambi RamuduGanesan Ponesakki

Published in: Molecular biology reports (2021)

For the first time, our results demonstrate that neoxanthin offers adequate protection against stress-mediated cytotoxicity in hepatocytes by activating the intracellular antioxidant defense system and blocking apoptosis.

Keyphrases

oxidative stress
diabetic rats
signaling pathway
endoplasmic reticulum stress
cell cycle arrest
cell death
anti inflammatory
high glucose
mouse model
drug induced
cell proliferation