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High-Frequency Spinal Stimulation Suppresses Microglial Kaiso-P2X7 Receptor Axis-Induced Inflammation to Alleviate Neuropathic Pain in Rats.

Jing YuStanley WongZhinan LinZhiming ShanChaoyang FanZhengyuan XiaMartin C H CheungXiaowei ZhuJessica Aijia LiuChi Wai Cheung
Published in: Annals of neurology (2024)
HF10 SCS could improve the immunopathologic state in the SDH, extending its benefits beyond symptom relief. Targeting the Kaiso-P2X7R axis may enhance Con SCS therapy and offer a new strategy for pain management. ANN NEUROL 2024;95:966-983.
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