Frequent PTEN loss and differential HER2/PI3K signaling pathway alterations in salivary duct carcinoma: Implications for targeted therapy.

Pierre SaintignyYoshitsugu MitaniKristen B PytyniaRenata FerrarottoDianna B RobertsRandal S WeberMerrill S KiesSankar N MaitySue-Hwa LinAdel K El-Naggar

Published in: Cancer (2018)

The current analyses reveal frequent PTEN loss and mutually exclusive alterations of key PI3K pathway members in SDC and demonstrate in vitro evidence of a response to pan-PI3K inhibitors. These results provide a framework for a biomarker-based substratification of patients with SDC in future targeted therapy. Cancer 2018;124:3523-32. © 2018 American Cancer Society.

Keyphrases

papillary thyroid
pi k akt
signaling pathway
squamous cell
cell proliferation
genome wide
gene expression
childhood cancer
dna methylation
current status
young adults