8-Aza Quinazolines as Brain Penetrant SOS1 Inhibitors for Treating Cancer.

Published in: ACS medicinal chemistry letters (2023)

Provided herein are 8-aza quinazolines as brain-penetrant SOS1 inhibitors, pharmaceutical compositions, use of such compounds in treating cancer, and processes for preparing such compounds.

Keyphrases

papillary thyroid
squamous cell
white matter
childhood cancer
squamous cell carcinoma
cerebral ischemia
young adults