Association of Plasma Leucine-Rich α-2 Glycoprotein 1, a Modulator of Transforming Growth Factor-β Signaling Pathway, With Incident Heart Failure in Individuals With Type 2 Diabetes.

Jian-Jun LiuSharon L T PekJiexun WangSylvia LiuKeven AngYi Ming ShaoJustin I-Shing TangResham L GurungSubramaniam TavintharanWern Ee TangChee Fang SumJian-Jun Liu

Published in: Diabetes care (2020)

Plasma LRG1 is associated with risks of incident HF and HHF, suggesting that it may potentially be involved in pathogenesis of HF in individuals with type 2 diabetes. Additional studies are warranted to determine whether LRG1 is a novel biomarker for HF risk stratification.

Keyphrases

transforming growth factor
acute heart failure
epithelial mesenchymal transition
heart failure
signaling pathway
cardiovascular disease
pi k akt
atrial fibrillation
left ventricular
human health
induced apoptosis
cardiac resynchronization therapy
oxidative stress