V1bR enhances glucose-stimulated insulin secretion by paracrine production of glucagon which activates GLP-1 receptor.

Ying YunShimeng GuoXin Xie

Published in: Cell & bioscience (2024)

Our study revealed a crosstalk between α and β cells initiated by AVP/V1bR and mediated by glucagon/GLP-1R, providing a mechanism to develop new glucose-controlling therapies targeting V1bR.

Keyphrases

induced apoptosis
blood glucose
cell cycle arrest
cancer therapy
signaling pathway
cell death
drug delivery
adipose tissue
metabolic syndrome
insulin resistance
skeletal muscle