GLP-1 increases heart rate by a direct action on the sinus node.
Anniek Frederike LubberdingSimon VeedfaldJonathan Samuel AchterSarah Dalgas NissenLuca SoattinAndrea SorrentinoEstefania Torres VegaBenedikt LinzCaroline Harriet Eggert EggertsenJohn MulveySigne TorängSara Agnete LarsenAnne NissenLonnie Grove PetersenSecil Erbil BilirBo Hjorth BentzenMette Marie RosenkildeBolette HartmannThomas Nikolaj Bang LilleørSaddiq QaziChristian Holdflod MøllerJacob Tfelt-HansenStefan Michael SattlerThomas JespersenJens Juul HolstAlicia LundbyPublished in: Cardiovascular research (2024)
GLP-1 has direct chronotropic effects on the heart mediated by GLP-1 receptors in pacemaker cells of the sinus node, inducing changes in action potential morphology and the leading pacemaker site through a calcium signaling response characterized by PKA-dependent phosphorylation of Ca2+ cycling proteins involved in pace making. Targeting the pacemaker calcium clock may be a strategy to lower heart rate in GLP-1 RA recipients.
Keyphrases
- heart rate
- heart rate variability
- blood pressure
- vena cava
- induced apoptosis
- lymph node
- heart failure
- rheumatoid arthritis
- cell cycle arrest
- atrial fibrillation
- cancer therapy
- endoplasmic reticulum stress
- cell death
- oxidative stress
- drug delivery
- cell proliferation
- disease activity
- systemic sclerosis
- ankylosing spondylitis
- idiopathic pulmonary fibrosis