β-Catenin gene promoter hypermethylation by reactive oxygen species correlates with the migratory and invasive potentials of colon cancer cells.

Suhrid BanskotaSadan DahalEunju KwonDong Young KimJung-Ae Kim

Published in: Cellular oncology (Dordrecht) (2018)

From our data we conclude that the extent of CTNNB1 gene promoter methylation by reactive oxygen species correlates with the migratory and invasive abilities of colon cancer cells. Our results suggest that epigenetic regulation of CTNNB1 may serve as a novel avenue to block colon cancer cell migration and invasion.

Keyphrases

reactive oxygen species
dna methylation
genome wide
copy number
transcription factor
gene expression
genome wide identification
epithelial mesenchymal transition
cell proliferation
electronic health record
machine learning
signaling pathway
genome wide analysis
deep learning