Melatonin influences the biological characteristics of keloid fibroblasts through the Erk and Smad signalling pathways.

Shaobin HuangWuguo DengYunxian DongZhicheng HuYi ZhangPeng WangXiaoling CaoMiao ChenPu ChengHailin XuWenkai ZhuBing Tang Jiayuan Zhu

Published in: Burns & trauma (2023)

Collectively, melatonin may inhibit the Erk and Smad pathways through the membrane receptor MT2 to alter the cell functions of KFs, while combination with 5-FU could exert even more inhibitory effects in KFs through simultaneous suppression of multiple signalling pathways.

Keyphrases

signaling pathway
epithelial mesenchymal transition
transforming growth factor
cell proliferation
pi k akt
single cell
stem cells
mesenchymal stem cells
extracellular matrix
bone marrow