LPS from P. gingivalis Negatively Alters Gingival Cell Mitochondrial Bioenergetics.
Kiran NapaAndrea C BaederJeffrey E WittSarah T RayburnMadison G MillerBlake W DallonJonathan L GibbsShalene H WilcoxDuane R WindenJared H SmithPaul R ReynoldsBenjamin T BikmanPublished in: International journal of dentistry (2017)
LPS elicits an increase in gingival cell mitochondria content, with a subsequent increase in reactive oxygen species production (i.e., H2O2), despite a paradoxical reduction in ATP generation. These findings provide an insight into the nature of oxidative stress in oral inflammatory pathologies.