Tumor-infiltrating lymphocytes predict improved overall survival after post-mastectomy radiotherapy: a study of the randomized DBCG82bc cohort.
Trine TrammHanne VinterPernille VahlDemet ÖzcanLine BrøndumJens OvergaardPublished in: Acta oncologica (Stockholm, Sweden) (2021)
High TILs predict improved OS from PMRT in BC patients, and the association appeared especially strong for ER- tumors. A trend in the association between high TILs and reduced risk of DM after PMRT was seen. These findings may indicate that RT triggers an immune response inducing a systemic effect outside the treatment field.
Keyphrases
- immune response
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- ejection fraction
- early stage
- open label
- prognostic factors
- radiation therapy
- peritoneal dialysis
- double blind
- clinical trial
- locally advanced
- estrogen receptor
- metabolic syndrome
- radiation induced
- phase iii
- placebo controlled
- replacement therapy
- rectal cancer
- smoking cessation