ZIF-8 with cationic defects toward efficient 125 I 2 uptake for in vitro radiotherapy of colon cancer.

Xin-Xin TianYi-Tong LiuYan LiXin-Yu QiuWen-Hua Zhang David James YoungQiu Chen

Published in: Chemical communications (Cambridge, England) (2022)

Introducing 2,3-dimethyl-1 H -imidazol-3-ium iodide (Dmim) as a monodentate ligand during the preparation of ZIF-8 yields ZIF-8 + (50) and ZIF-8 + (38) with cationic 'missing linker' defects. ZIF-8 + (38) adsorbs 125 I 2 and the resulting radioactive host-guest complex exhibits in vitro cytotoxicity comparable to that of Na 125 I against colon cancer cell line CT26.

Keyphrases

computed tomography
early stage
radiation therapy
image quality
mass spectrometry
locally advanced
radiation induced
high resolution
liquid chromatography
metal organic framework