The Novel Lysosomal Autophagy Inhibitor (ROC-325) Ameliorates Experimental Pulmonary Hypertension.

Changlei BaoShuxin LiangYing HanZi YangShiyun LiuYanan SunShichuang ZhengYuzhu LiTing WangYali GuKang WuStephen M BlackJian WangSteffan T NawrockiJennifer S CarewJason X-J Yuan Haiyang Tang

Published in: Hypertension (Dallas, Tex. : 1979) (2022)

These data indicate that ROC-325 is a promising novel agent for the treatment of PH that inhibits autophagy, downregulates HIF levels, and increases nitric oxide production.

Keyphrases

nitric oxide
pulmonary hypertension
cell death
endoplasmic reticulum stress
oxidative stress
signaling pathway
electronic health record
mouse model
endothelial cells
hydrogen peroxide
big data
nitric oxide synthase
machine learning
coronary artery
replacement therapy
deep learning