ITGBL1 promotes cell migration and invasion through stimulating the TGF-β signalling pathway in hepatocellular carcinoma.

Wei HuangDemin YuMingjie WangYue HanJunyu LinDong WeiJialin CaiBin LiPeizhan ChenXin-Xin Zhang

Published in: Cell proliferation (2020)

These findings suggested that ITGBL1 promoted migration and invasion in HCC cells by stimulating the TGF-β/Smads signalling pathway. ITGBL1 could be a promising prognostic biomarker, as well as a potential therapeutic target in HCC.

Keyphrases

transforming growth factor
induced apoptosis
epithelial mesenchymal transition
cell cycle arrest
single cell
cell therapy
endoplasmic reticulum stress
signaling pathway
stem cells
oxidative stress
mesenchymal stem cells