Unveiling the therapeutic potential of Dl-3-n-butylphthalide in NTG-induced migraine mouse: activating the Nrf2 pathway to alleviate oxidative stress and neuroinflammation.

Yingyuan LiuZihua GongDeqi ZhaiChunxiao YangGuangshuang LuShuqing WangShaobo XiaoChenhao LiLudan ChenXiaoxue LinShuhua ZhangSheng-Yuan Yu Zhao Dong

Published in: The journal of headache and pain (2024)

Our data suggest that NBP may alleviate migraine by activating the Nrf2 pathway to reduce oxidative stress and inflammation in migraine mouse models, confirming that it may be a potential drug for the treatment of migraine.

Keyphrases

oxidative stress
diabetic rats
ischemia reperfusion injury
dna damage
signaling pathway
induced apoptosis
mouse model
traumatic brain injury
emergency department
lipopolysaccharide induced
electronic health record
high glucose
machine learning
lps induced
endothelial cells
replacement therapy
data analysis