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Biomarkers for Pregnancy Latency Prediction after Preterm Premature Rupture of Membranes-A Systematic Review.

Stepan FeduniwFrancesco ChiricoMichal CiebieraNatalia Zeber-LubeckaDiana MassalskaMagdalena ZgliczynskaAgnieszka Aleksandra StrojnyAgnieszka Szarpak
Published in: International journal of molecular sciences (2023)
Preterm premature rupture of membranes, leading to preterm birth, is associated with neonatal and maternal morbidity and mortality. The study aimed to review the existing data on the best predictive value of pregnancy latency for known biomarkers in pregnancies after preterm premature rupture of membranes. The following databases were screened for the purposes of this systematic review: Pubmed/MEDLINE, Web of Science, EMBASE, Scopus, and the Cochrane Library. The study was conducted according to the PRISMA guidelines for systematic reviews. Only a few studies assessed biomarkers predicting pregnancy duration after PPROM. IL-6, IL-8, CRP, IL1RA, s-endoglin, βhCG, AFP, PCT, urea, creatinine, oxygen radical absorbance capacity, MDA, lipocalin-2, endotoxin activity, MMP-8, MMP-9 and S100 A8/A9 were found to have a positive predictive value for delivery timing prediction. Proinflammatory biomarkers, such as IL-6 or CRP, proved to be best correlated with delivery timing, independent of the occurrence of intrauterine infection.
Keyphrases
  • preterm birth
  • low birth weight
  • gestational age
  • systematic review
  • birth weight
  • meta analyses
  • rheumatoid arthritis
  • pregnancy outcomes
  • public health
  • body mass index
  • preterm infants
  • systemic sclerosis