Effect of preoperative administration of systemic alpha-2 agonists on postoperative pain: a systematic review and meta-analysis.

Published in: Anesthesia and pain medicine (2020)

In this meta-analysis, high degree of heterogeneity limits the preoperative administration of alpha-2 agonists in reducing postoperative opioid consumption and pain intensity. Future powered large RCTs are required to increase the certainty of evidence on the effect in reducing postoperative opioid consumption and pain intensity.

Keyphrases

chronic pain
pain management
patients undergoing
postoperative pain
systematic review
high intensity
neuropathic pain
meta analyses
single cell
spinal cord injury