Population Pharmacokinetic Model of Methotrexate in Brazilian Pediatric Patients with Acute Lymphoblastic Leukemia.

Pricilla de Oliveira HenzAmanda Valle PinhattiLauro José GregianinManoela MartinsMarina CurraBibiana Verlindo de AraújoTeresa Dalla Costa

Published in: Pharmaceutical research (2023)

The first popPK model of MTX was developed for Brazilian pediatric ALL patients, which showed that inter-individual variability was explained by renal function and factors related to body size.

Keyphrases

acute lymphoblastic leukemia
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
allogeneic hematopoietic stem cell transplantation
young adults