dl-3-n-butylphthalide preserves white matter integrity and alleviates cognitive impairment in mice with chronic cerebral hypoperfusion.

Qin-Yu HanHe ZhangXi ZhangDong-Sheng HeSun-Wei WangXiang CaoYu-Tian DaiYun XuLi-Juan Han

Published in: CNS neuroscience & therapeutics (2019)

Our results indicated that NBP represents a promising therapy for chronic cerebral hypoperfusion-induced white matter damage and cognitive impairment.

Keyphrases

cognitive impairment
white matter
multiple sclerosis
subarachnoid hemorrhage
drug induced
oxidative stress
high glucose
cerebral ischemia
mouse model
type diabetes
metabolic syndrome
endothelial cells
skeletal muscle
adipose tissue