Generation of a humanized FXII knock-in mouse-A powerful model system to test novel anti-thrombotic agents.

Sarah BeckDavid StegnerStefan LorochAyesha A BaigVanessa GöbCornelia SchumbrutzkiEva EilersAlbert SickmannFrauke MayMarc W NolteCon PanousisBernhard Nieswandt

Published in: Journal of thrombosis and haemostasis : JTH (2021)

These data establish the newly generated hF12KI mouse as a powerful and unique model system for in vivo studies on anti-FXII(a) biologics, supporting the development of efficient and safe human FXII(a) inhibitors.

Keyphrases

endothelial cells
electronic health record
squamous cell carcinoma
induced pluripotent stem cells
radiation therapy
data analysis
atrial fibrillation
locally advanced