A brain-penetrant microtubule-targeting agent that disrupts hallmarks of glioma tumorigenesis.

Eric A HornePhilippe DiazPatrick J CiminoErik JungCong XuErnest HamelMichael WagenbachDebra KumasakaNicholas B WagelingDaniel D AzorínFrank WinklerLinda G WordemanEric C HollandNephi Stella

Published in: Neuro-oncology advances (2020)

Our study identifies hallmarks of glioma tumorigenesis that are sensitive to MTAs and reports ST-401 as a promising chemical scaffold to develop brain-penetrant MTAs.

Keyphrases

resting state
white matter
functional connectivity
cerebral ischemia
genome wide
emergency department
cancer therapy
gene expression
multiple sclerosis
tissue engineering