Small Fiber Neuropathy Incidence, Prevalence, Longitudinal Impairments, and Disability.
Stephen A JohnsonKamal ShoumanShahar ShellyPaola SandroniSarah E BeriniP James B DyckErnest Matthew HoffmanJay MandrekarZhiyv NiuChristopher J LambPhillip A LowWolfgang SingerMichelle L MauermannJohn MillsDivyanshu DubeyNathan P StaffChristopher J KleinPublished in: Neurology (2021)
Isolated SFN is uncommon but increasing in incidence. Most patients do not develop major neurologic impairments and disability but have multiple comorbid conditions, including cardiovascular ischemic events, and increased mortality from SFN onsets. Development of large fiber involvements and diabetes are common over time. Targeted testing facilitates interventional therapies for diabetes but also rheumatologic and rare genetic forms.
Keyphrases
- risk factors
- type diabetes
- end stage renal disease
- cardiovascular disease
- multiple sclerosis
- chronic kidney disease
- newly diagnosed
- glycemic control
- ejection fraction
- prognostic factors
- peritoneal dialysis
- genome wide
- cancer therapy
- cardiovascular events
- metabolic syndrome
- skeletal muscle
- oxidative stress
- drug delivery
- patient reported outcomes
- brain injury
- ischemia reperfusion injury
- copy number