Epigenetic risk score improves prostate cancer risk assessment.
Leander Van NesteJack GroskopfWilliam E GrizzleGeorge W AdamsMark S DeGuentherPeter N KolettisJames E BryantGary P KearneyMichael C KearneyWim Van CriekingeSandra M GastonPublished in: The Prostate (2017)
In men diagnosed with PCa, DNA-methylation profiling can detect under-sampled high-risk PCa in prostate biopsy specimens through a field effect. Predictive accuracy increased when EpiScore was combined with other clinical risk factors. These results suggest that EpiScore could aid in the detection of occult high-grade disease at the time of diagnosis, thereby improving the selection of candidates for Active Surveillance.
Keyphrases
- prostate cancer
- dna methylation
- high grade
- risk factors
- risk assessment
- radical prostatectomy
- gene expression
- fine needle aspiration
- genome wide
- low grade
- ultrasound guided
- loop mediated isothermal amplification
- human health
- heavy metals
- single cell
- real time pcr
- middle aged
- label free
- copy number
- benign prostatic hyperplasia