CEACAM6 Promotes Lung Metastasis via Enhancing Proliferation, Migration and Suppressing Apoptosis of Prostate Cancer Cells.
Alireza SarajiKatharina WulfJanine Stegmann-FrehseDuan KangAnne OffermannGevorg ShaghoyanDanny JonigkMark Philipp KühnelSven PernerJutta KirfelVerena SailerPublished in: Cancer genomics & proteomics (2024)
Functional validation revealed that CEACAM6 might play an important role in fostering metastatic spread to the lung of PCa patients via enhancing proliferation, migration and suppressing apoptosis in PC-3 and LNCaP cells. CEACAM6 might pose an attractive therapeutic target to prevent metastatic disease.
Keyphrases
- cell cycle arrest
- signaling pathway
- induced apoptosis
- pi k akt
- endoplasmic reticulum stress
- cell death
- squamous cell carcinoma
- oxidative stress
- small cell lung cancer
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- single cell
- patient reported outcomes
- patient reported