Germline BRCA2 pathogenic variants in pediatric ganglioglioma: Case report and review of the literature.

Anya GuptaMirna LechpammerNicole M Brossier

Published in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (2024)

BRCA2 germline variants may increase the risk of developing some types of pediatric brain tumors, but further study is needed to determine its effect on low-grade glioma formation.

Keyphrases

low grade
high grade
copy number
dna repair
gene expression
dna damage
dna methylation
oxidative stress
young adults
childhood cancer