CAR T cells Targeting Human Immunoglobulin Light Chains Eradicate Mature B-cell Malignancies While Sparing a Subset of Normal B Cells.

Raghuveer RanganathanPeishun ShouSarah AhnChuang SunJohn WestBarbara SavoldoGianpietro Dotti

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Adoptive transfer of CAR.λ and CAR.κ-T cells represents a useful and alternative modality to CAR.CD19-T cells in treating mature B-cell malignancies with minimal impact on humoral immunity.See related commentary by Jain and Locke, p. 5736.

Keyphrases

induced apoptosis
endothelial cells
immune response
cell cycle arrest
cell therapy
induced pluripotent stem cells
cancer therapy
robot assisted
stem cells
cell proliferation
drug delivery
mesenchymal stem cells