Development and Feasibility of a Porcine Model of Amlodipine Toxicity.

Sean P BoleyRebecca B MackenzieJenna M LeRoyKristin M EngebretsenSamuel J Stellpflug

Published in: Journal of medical toxicology : official journal of the American College of Medical Toxicology (2019)

This study demonstrates a potentially repeatable model of amlodipine-induced toxic shock using intravenous administration of amlodipine and several methodological considerations for researchers undertaking similar work.

Keyphrases

hypertensive patients
high glucose
oxidative stress
high dose
endothelial cells