An intracellular, non-oxidative factor activates in vitro chromatin fragmentation in pig sperm.

Estel Viñolas-VergésMichael L DustinFerran GarrigaSergi BonetYentel Mateo-OteroJordi Ribas-Maynou

Published in: Biological research (2023)

were observed to induce SCF in ejaculated sperm, resulting in DNA cleavage at TLRs. The activation of this mechanism by an intracellular, non-oxidative factor sheds light on the events taking place during sperm cell death.

Keyphrases

cell death
reactive oxygen species
gene expression
transcription factor
circulating tumor
dna binding
oxidative stress
cell cycle arrest