Role for Granulocyte Colony-Stimulating Factor in Neutrophilic Extramedullary Myelopoiesis in a Murine Model of Systemic Juvenile Idiopathic Arthritis.

Bert Malengier-DevliesEline BernaertsKourosh AhmadzadehJessica FiltjensJessica VandenhauteBram BoeckxOliver BurtonAmber De VisscherTania MiteraNele BerghmansGeert VerbekeAdrian ListonDiether LambrechtsMieke GouwyCarine WoutersPatrick Matthys

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

We describe the role of G-CSF in a mouse model of systemic JIA and suggest an important role for G-CSF-induced myelopoiesis and neutrophilia in regulating the development of arthritis.

Keyphrases

juvenile idiopathic arthritis
mouse model
disease activity
drug induced
diabetic rats
oxidative stress
cerebrospinal fluid
systemic lupus erythematosus
endothelial cells
recombinant human