Uridine 5'-Diphospho-glucuronosyltransferase 1A3 (UGT1A3) Prediction of Hepatic Clearance of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) Substrate Telmisartan by Glucuronidation Using In Vitro-In Vivo Extrapolation (IVIVE).
Ewelina Gabor-WorwaAnna Kowal-ChwastNilesh GaudDawid GogolaPeter LittlewoodMarek SmoluchKrzysztof BrzózkaKamil KusPublished in: European journal of drug metabolism and pharmacokinetics (2024)
The study showed that taking into consideration hepatic uptake of a drug allows us to obtain satisfactory scaling factors, hence enabling the prediction of in vivo hepatic glucuronidation from in vitro data.