A subset of activated fibroblasts is associated with distant relapse in early luminal breast cancer.
Claire BonneauAntoine ElièsYann KiefferBrigitte BourachotSylvain LadoireFloriane PelonDelphine HequetJean-Marc GuinebretièreChristophe BlanchetAnne Vincent-SalomonRoman RouzierFatima Mechta-GrigoriouPublished in: Breast cancer research : BCR (2020)
This study shows that distant recurrence in T1N0 BC is strongly associated with the presence of CAF-S1 fibroblasts. Moreover, we identify CDH11 as a key player in CAF-S1-mediated pro-metastatic activity. This is independent of tumor cells and represents a new prognostic factor. These results could assist clinicians in identifying luminal BC patients with high risk of relapse. Targeted therapies against CAF-S1 using anti-FAP antibody or CDH11-targeting compounds might help in preventing relapse for such patients with activated stroma.