DXA-equivalent quantification of bone mineral density using dual-layer spectral CT scout scans.
Alexis LaugeretteBenedikt J SchwaigerKevin BrownLena C FrerkingFelix K KoppKai MeiThorsten SellererJan KirschkeThomas BaumAlexandra S GersingDaniela PfeifferAlexander A FingerleErnst J RummenyRoland ProksaPeter B NoëlFranz PfeifferPublished in: European radiology (2019)
• 2D scout scans (localizer radiographs) from a dual-layer spectral CT scanner, which are mandatory parts of a CT examination, can be used to automatically determine areal bone mineral density (aBMD) at the spine. • The presented method allowed fast (< 25 s/patient), semi-automatic, and reliable DXA-equivalent aBMD measurements for state-of-the-art DXA phantoms at different tube settings and for various patient habitus, as well as for sample patients. • Considering the number of CT scout scan acquisitions performed worldwide on a daily basis, the presented technique could enable truly opportunistic osteoporosis screening with DXA-equivalent metrics, without involving higher radiation exposure since it only processes existing data that is acquired during each CT scan.
Keyphrases
- dual energy
- bone mineral density
- computed tomography
- postmenopausal women
- image quality
- body composition
- contrast enhanced
- magnetic resonance imaging
- end stage renal disease
- machine learning
- chronic kidney disease
- case report
- newly diagnosed
- prognostic factors
- magnetic resonance
- physical activity
- deep learning
- artificial intelligence
- patient reported