Integrated Analysis of Crucial Genes and miRNAs Associated with Osteoporotic Fracture of Type 2 Diabetes.
Liang MoZhangzheng WangHaoran HuangJianxiong LiChao MaJiahao ZhangFayi HuangWei HeYuhao LiuChi ZhouPublished in: BioMed research international (2022)
The study uncovered several important genes, miRNAs, and pathological mechanisms involved in diabetic skeletal fragility, among which the PI3K-Akt signaling pathway and AGE-RAGE signaling pathway in diabetic complications may play important roles.
Keyphrases
- type diabetes
- signaling pathway
- pi k akt
- genome wide
- wound healing
- epithelial mesenchymal transition
- bioinformatics analysis
- glycemic control
- induced apoptosis
- cardiovascular disease
- genome wide identification
- insulin resistance
- bone mineral density
- dna methylation
- gene expression
- adipose tissue
- hip fracture
- transcription factor
- cell proliferation
- endoplasmic reticulum stress
- postmenopausal women