Circulating immune cell landscape and T-cell abnormalities in patients with moyamoya disease.

Peicong GeChuming TaoWenjing WangQiheng HeChenglong LiuZhiyao ZhengSiqi MouBojian ZhangXingju LiuQian ZhangRong WangHao LiDong ZhangJizong Zhao

Published in: Clinical and translational medicine (2024)

Our findings offer a comprehensive view of the circulating immune cell landscape in MMD patients. Immune dysregulation in patients with MMD was characterized by alterations in T-cell populations, including a decrease in effector T-cells and an increase in regulatory T-cells (Tregs), suggest a potential role for disrupted circulating immunity in the aetiology of MMD.

Keyphrases

regulatory t cells
end stage renal disease
dendritic cells
newly diagnosed
chronic kidney disease
ejection fraction
prognostic factors
single cell
peritoneal dialysis
patient reported outcomes
resting state
genetic diversity