IL-1β-Induced Elevation of Solute Carrier Family 7 Member 11 Promotes Hepatocellular Carcinoma Metastasis Through Up-regulating Programmed Death Ligand 1 and Colony-Stimulating Factor 1.
Qin HeMei LiuWenjie HuangXiaoping ChenBixiang ZhangTongyue ZhangYijun WangDanfei LiuMeng XieXiaoyu JiMengyu SunDean TianLimin XiaPublished in: Hepatology (Baltimore, Md.) (2021)
IL-1β-induced SLC7A11 overexpression up-regulated PD-L1 and CSF1 through the αKG/HIF1α axis, which promoted TAM and MDSC infiltration. Interruption of this oncogenic loop may provide a promising therapy strategy for the inhibition of SLC7A11-mediated HCC metastasis.