Feeding metformin during pregnancy and lactation periods improved learning and memory impairment in the rat offspring exposed to febrile seizure: Role of oxidative stress and inflammatory response.

Niloofar KhoshrooAli RahimiSamaneh KakhkiFatemeh KaffashanMaha MasoudiSoheil BaharlouFarimah Beheshti

Published in: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience (2024)

Considering the present research and related study in relation to metformin in ameliorating the epilepsy symptoms, there are numerous evidences on positive effect of metformin on seizure. Although the exact mechanism is unclear, the anti-oxidant effect of metformin is strongly supported.

Keyphrases

oxidative stress
inflammatory response
dna damage
high fat diet
human milk
physical activity
immune response
ischemia reperfusion injury
depressive symptoms
insulin resistance
low birth weight