Serum high-mobility group box 1 is associated with the onset and severity of acute exacerbation of idiopathic pulmonary fibrosis.
Kakuhiro YamaguchiHiroshi IwamotoShinjiro SakamotoYasushi HorimasuTakeshi MasudaShintaro MiyamotoTaku NakashimaShinichiro OhshimoKazunori FujitakaHironobu HamadaNoboru HattoriPublished in: Respirology (Carlton, Vic.) (2019)
Higher levels of serum HMGB1 predict earlier onset of AE in stable IPF patients and shorter survival in AE-IPF patients, indicating that HMGB1 is associated with acute deterioration of the disease.
Keyphrases
- idiopathic pulmonary fibrosis
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- liver failure
- peritoneal dialysis
- prognostic factors
- respiratory failure
- chronic obstructive pulmonary disease
- interstitial lung disease
- transcription factor
- systemic sclerosis
- extracorporeal membrane oxygenation
- aortic dissection