Combined serum biomarker analysis shows no benefit in the diagnosis of periprosthetic joint infection.
S M KlimF AmerstorferG GlehrG HauerM A SmolleLukas LeitnerA LeithnerM GlehrPublished in: International orthopaedics (2020)
In this study, multiple biomarkers were tested for their diagnostic performance, with CRP and fibrinogen showing the best results regarding the AUC, accuracy, sensitivity, and specificity. It was not possible to further increase the diagnostic accuracy by combining multiple biomarkers using sophisticated statistical methods.