Synergistic interaction of guanfacine or dexmedetomidine coadministered with lidocaine for cutaneous analgesia in rats.

An-Kuo ChouChong-Chi ChiuJhi-Joung WangYu-Wen ChenChing-Hsia Hung

Published in: Neurological research (2024)

We showed that guanfacine elicits dose-dependent cutaneous analgesia when administered subcutaneously. Lidocaine is less potent than guanfacine or dexmedetomidine. Both guanfacine and dexmedetomidine enhance the potency and duration of lidocaine. Better synergistic responses we are getting with guanfacine plus lidocaine.

Keyphrases

cardiac surgery
pain management
ultrasound guided
cancer therapy
postoperative pain
acute kidney injury
chronic pain
anti inflammatory