PBRM1 suppresses tumor growth as a novel p53 acetylation reader.

Published in: Molecular & cellular oncology (2020)

The reader(s) for acetylated tumor antigen p53 remains elusive. Here, PBRM1 (polybromo-1) is identified as a reader for acetylated lysine382 on p53 through its bromodomain 4 (BD4). PBRM1 BD4 mutants fail to support p53 transcriptional activity and suppress tumor growth. Thus PBRM1 suppresses tumor growth through p53 in kidney cancer.

Keyphrases

signaling pathway
papillary thyroid
gene expression
squamous cell
transcription factor
amino acid
lymph node metastasis
histone deacetylase
heat shock protein
wild type