E2F transcription factors promote tumorigenicity in pancreatic ductal adenocarcinoma.
Ludivine Bertonnier-BroutyJonas AnderssonTuomas KaprioJaana HagströmSara BsharatOlof AsplundGad HatemCaj HaglundHanna SeppänenRashmi B PrasadIsabella ArtnerPublished in: Cancer medicine (2024)
Our findings illustrate that E2F1 and E2F8 transcription factors are expressed in pancreatic progenitor and PDAC cells, where they contribute to tumor cell expansion by regulation of cell proliferation, viability, and cell migration making these genes attractive therapeutic targets and potential prognostic markers for pancreatic cancer.
Keyphrases
- cell migration
- transcription factor
- cell proliferation
- genome wide identification
- induced apoptosis
- cell cycle arrest
- single cell
- dna binding
- cell therapy
- genome wide
- pi k akt
- endoplasmic reticulum stress
- stem cells
- signaling pathway
- oxidative stress
- mesenchymal stem cells
- gene expression
- cell death
- climate change
- bone marrow