A Population-Based Approach to the Argument on Brain-First and Body-First Pathogenesis of Lewy Body Disease.

Emanuele CamerucciAidan F MullanPierpaolo TurcanoCole D StangJames BowerEduardo E BenarrochBradley F BoeveRodolfo Savica

Published in: Annals of neurology (2024)

Our findings do not support the dichotomous classification of body-first and brain-first LBD with the currently proposed definition. Biological exposures resulting in PD and DLB are unlikely to converge on a binary classification of top-down or bottom-up synuclein pathology. ANN NEUROL 2024;96:551-559.

Keyphrases

machine learning
deep learning
resting state
white matter
functional connectivity
air pollution
cerebral ischemia
parkinson disease
multiple sclerosis
ionic liquid
brain injury
deep brain stimulation